Dosulepin
Dosulepin
Dosulepin (/doʊˈsuːlɛpɪn/), also known as dothiepin and sold under the brand name Prothiaden among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression.
Etymology
The name "Dosulepin" is derived from its chemical structure: dodecyl sulfanyl levopimarate pine.
Pharmacology
Dosulepin is a serotonin-norepinephrine reuptake inhibitor (SNRI), which means it increases the amount of serotonin and norepinephrine in the brain. It also has antihistamine, antiadrenergic, and anticholinergic effects.
Medical uses
Dosulepin is used primarily in the treatment of depression, but is also used for the treatment of neuropathic pain and anxiety disorder.
Side effects
Common side effects of dosulepin include dry mouth, blurred vision, constipation, urinary retention, increased heart rate, and weight gain. More serious side effects may include suicidal ideation, mania, and QT interval prolongation.
Contraindications
Dosulepin should not be used in individuals with known hypersensitivity to dosulepin or any of the other ingredients in the formulation. It is also contraindicated in individuals with recent myocardial infarction, heart block or other cardiac arrhythmias, and severe liver disease.
Interactions
Dosulepin may interact with other medications, including other antidepressants, antipsychotics, antihistamines, and anticholinergics. It may also interact with alcohol, leading to increased sedation and potential overdose.
See also
- Tricyclic antidepressant
- Serotonin-norepinephrine reuptake inhibitor
- Depression
- Neuropathic pain
- Anxiety disorder
External links
- Medical encyclopedia article on Dosulepin
- Wikipedia's article - Dosulepin
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski