Inflammaging
Inflammaging
Inflammaging (pronounced: /ɪnˈflæm.ə.dʒɪŋ/) is a term coined in the field of biogerontology to describe a chronic, low-grade inflammation that is associated with age-related morbidity and senescence. The term is a portmanteau of "inflammation" and "aging".
Etymology
The term "Inflammaging" was first introduced by Claudio Franceschi and his team in 2000. It is a combination of the words "inflammation" and "aging", reflecting the concept that aging is accompanied by a low-grade chronic inflammatory status.
Definition
Inflammaging is characterized by the upregulation of the immune system, resulting in persistent inflammation and a higher susceptibility to pathogens. It is considered a significant risk factor for both morbidity and mortality in the elderly people as it contributes to the pathogenesis of aging-related diseases such as cardiovascular diseases, type 2 diabetes, Alzheimer's disease, and cancer.
Related Terms
- Biogerontology: The study of the biological aspects of aging.
- Senescence: The condition or process of deterioration with age.
- Morbidity: The condition of being diseased.
- Pathogens: A bacterium, virus, or other microorganism that can cause disease.
See Also
External links
- Medical encyclopedia article on Inflammaging
- Wikipedia's article - Inflammaging
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