Macrophage-1 antigen
Macrophage-1 Antigen
Macrophage-1 Antigen (pronunciation: ma·cro·phage-1 an·ti·gen), also known as CD11b or Integrin alpha M, is a protein that in humans is encoded by the ITGAM gene.
Etymology
The term Macrophage-1 Antigen is derived from the Greek words "makros" meaning large, "phagein" meaning to eat, and "antigen" from the Greek "anti-" meaning against and "-gen", from "genes" meaning born. This term is used to describe a type of protein that is found on the surface of certain cells, including macrophages, which are large cells that consume foreign particles and cell debris.
Function
Macrophage-1 Antigen is part of the integrin family and is primarily expressed on the surface of leukocytes (white blood cells), including monocytes, neutrophils, natural killer cells, and granulocytes. It plays a crucial role in the adhesion and migration of these cells, and is also involved in the process of phagocytosis and cell-mediated immunity.
Clinical Significance
Alterations in the Macrophage-1 Antigen have been associated with several diseases, including Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), and Crohn's Disease. It is also a potential target for therapeutic interventions in these diseases.
Related Terms
- Integrin
- Leukocytes
- Monocytes
- Neutrophils
- Natural Killer Cells
- Granulocytes
- Phagocytosis
- Cell-mediated immunity
- Systemic Lupus Erythematosus
- Rheumatoid Arthritis
- Crohn's Disease
External links
- Medical encyclopedia article on Macrophage-1 antigen
- Wikipedia's article - Macrophage-1 antigen
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