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Information about Quetiapine

Quetiapine is an atypical antipsychotic used in the treatment of schizophrenia and bipolar disorder.

Liver safety of Quetiapine

Use of quetiapine has been associated with serum aminotransferase elevations and in rare instances with clinically apparent acute liver injury.

Mechanism of action of Quetiapine

Quetiapine (kwe tye' a peen) is an atypical antipsychotic and dibenzodiazepine derivative which appears to act as a dopamine (D1-4) and serotonin (5-HT2) receptor antagonist. It also may have activity against histamine and alpha adrenergic receptors. Quetiapine is indicated for the treatment of schizophrenia and as either monotherapy or adjunctive therapy for acute manic episodes or as maintenance therapy in bipolar I disorder. It is also used in treatment of depressive episodes associated with bipolar I or II disorde and for major depressive disorders in combination with antidepressants.

FDA approval information for Quetiapine

Quetiapine was approved for use in the United States in 1997 and is still widely used.

Dosage and administration for Quetiapine

Quetiapine is available as tablets of 25, 50, 100, 200, 300 and 400 mg under the brand name Seroquel. Typical doses vary from 300 to 800 mg daily given in two divided doses. Extended release forms are also available for once daily dosing.

Side effects of Quetiapine

Common side effects include dizziness, sedation, somnolence, dry mouth, constipation, weakness, postural hypotension, increased appetite and weight gain. Rare, but potentially severe adverse events include neuroleptic malignant syndrome, tardive dyskinesia, severe dyslipidemia, diabetes, weight gain, hypotension, bone marrow suppression and cataracts.

Antipsychotic agents

First Generation

Second Generation (Atypicals)

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