Quinupristin-dalfopristin

Quinupristin-dalfopristin (pronounced as kwin-uh-pris-tin dal-fo-pris-tin) is a combination of two antibiotics, quinupristin and dalfopristin, used to treat certain types of bacterial infections.

Etymology

The names 'quinupristin' and 'dalfopristin' are derived from their chemical structures. Quinupristin is a derivative of pristinamycin IIA and dalfopristin is a derivative of pristinamycin IA. Both pristinamycins are part of the streptogramin group of antibiotics, produced by certain species of Streptomyces bacteria.

Usage

Quinupristin-dalfopristin is used to treat serious or life-threatening infections caused by susceptible bacteria, including vancomycin-resistant Enterococcus faecium (VREF) and methicillin-resistant Staphylococcus aureus (MRSA). It is administered intravenously.

Mechanism of Action

Quinupristin-dalfopristin works by inhibiting the bacterial ribosome, which is essential for protein synthesis. Quinupristin binds to the 50S subunit of the ribosome, inhibiting the elongation of the peptide chain, while dalfopristin binds to a nearby site, causing a conformational change that enhances the binding of quinupristin.

Related Terms

External links

Medical encyclopedia article on Quinupristin-dalfopristin
Wikipedia's article - Quinupristin-dalfopristin

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Quinupristin-dalfopristin