Sigma-2 receptor

Sigma-2 Receptor

The Sigma-2 receptor (pronunciation: SIG-muh too ree-SEP-ter) is a protein that is part of the Sigma receptor family. It is involved in various physiological processes and has been implicated in several diseases, including cancer and neurological disorders.

Etymology

The term "Sigma-2 receptor" is derived from the Greek letter Sigma, which is used in biochemistry to denote a specific type of binding site in a protein, and the number "2", indicating that it is the second subtype of this receptor family to be discovered.

Function

The Sigma-2 receptor is primarily located in the endoplasmic reticulum, a cellular organelle involved in protein synthesis and folding. It is thought to play a role in cell proliferation, apoptosis, and lipid transport. The exact function of the Sigma-2 receptor is still under investigation, but it is known to interact with various types of drugs, including antipsychotics, antidepressants, and anesthetics.

Clinical Significance

The Sigma-2 receptor has been implicated in several diseases. In cancer, it is overexpressed in many types of tumors, making it a potential target for cancer therapy. In neurological disorders, alterations in Sigma-2 receptor function have been linked to conditions such as Alzheimer's disease, Parkinson's disease, and schizophrenia.

Related Terms

• Sigma receptor
• Endoplasmic reticulum
• Cell proliferation
• Apoptosis
• Lipid transport
• Antipsychotics
• Antidepressants
• Anesthetics
• Cancer therapy
• Alzheimer's disease
• Parkinson's disease
• Schizophrenia

External links

• Medical encyclopedia article on Sigma-2 receptor
• Wikipedia's article - Sigma-2 receptor

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