ARID2

ARID2 (AT-rich interaction domain 2) is a protein that in humans is encoded by the ARID2 gene. It is a subunit of the PBAF (Polybromo- and BRG1-associated factor-containing complex) form of the SWI/SNF chromatin remodeling complex.

File:Protein ARID1B PDB 2cxy.png

Structure of the ARID2 protein.

Function

The ARID2 protein is a subunit of the PBAF form of the SWI/SNF chromatin remodeling complex. This complex plays a crucial role in transcription by remodeling chromatin to allow access of the transcription machinery to target DNA sequences. The ARID2 protein contains an AT-rich interaction domain (ARID), which is a DNA-binding domain that can bind to AT-rich sequences in the promoter regions of several genes.

Clinical significance

Mutations in the ARID2 gene have been associated with several types of cancer, including hepatocellular carcinoma, melanoma, and lung cancer. These mutations are thought to disrupt the function of the PBAF complex, leading to abnormal gene expression and promoting the development of cancer.

Research

Research into the role of ARID2 in cancer is ongoing. Current studies are focused on understanding how mutations in the ARID2 gene contribute to cancer development and progression, and on developing targeted therapies that can correct or compensate for these mutations.

See also

• SWI/SNF
• Chromatin remodeling
• AT-rich interaction domain