Bilateral renal agenesis

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Bilateral Renal Agenesis

Bilateral renal agenesis (pronunciation: bi-lat-er-al re-nal a-gen-e-sis) is a rare congenital disorder characterized by the absence of both kidneys at birth. The term originates from the Latin words "bi" meaning two, "lateral" meaning side, "renal" referring to the kidneys, and "agenesis" meaning lack of formation.

Definition

Bilateral renal agenesis is a condition in which a newborn is born without both kidneys. This condition is often fatal and is associated with low amniotic fluid levels, leading to underdeveloped lungs (pulmonary hypoplasia) and distinctive facial features (Potter's sequence).

Causes

The exact cause of bilateral renal agenesis is unknown, but it is thought to be due to a combination of genetic and environmental factors. Mutations in the RET gene have been associated with this condition.

Symptoms

The most common symptoms of bilateral renal agenesis include lack of urine production, underdeveloped lungs, and distinctive facial features. Other symptoms may include clubbed feet and undeveloped sex organs.

Diagnosis

Bilateral renal agenesis can be diagnosed through prenatal ultrasound, which can detect the absence of kidneys and low levels of amniotic fluid. After birth, physical examination and imaging tests can confirm the diagnosis.

Treatment

There is currently no cure for bilateral renal agenesis. Treatment is supportive and may include interventions to manage symptoms and complications.

Prognosis

The prognosis for bilateral renal agenesis is generally poor, with most infants not surviving past the first few days of life. However, with advances in medical care, some children with this condition have survived into adolescence and adulthood.

See Also

External links

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