Cancer in adolescents and young adults

Cancer in adolescents and young adults
Synonyms	AYA cancer
Pronounce	N/A
Specialty	N/A
Symptoms	Varies by cancer type; may include fatigue, pain, weight loss, lumps, swelling
Complications	Metastasis, secondary cancer, psychosocial issues
Onset	Ages 15–39
Duration	Varies by cancer type and stage
Types	Leukemia, lymphoma, melanoma, sarcoma, testicular cancer, breast cancer, thyroid cancer, colorectal cancer
Causes	Genetic factors, environmental factors, lifestyle factors
Risks	Family history, genetic predisposition, radiation exposure, smoking, obesity
Diagnosis	Medical imaging, biopsy, blood tests
Differential diagnosis	Other benign tumors, infectious diseases
Prevention	Healthy lifestyle, vaccination, screening
Treatment	Surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy
Medication	Chemotherapeutic agents, targeted drugs, hormonal therapy
Prognosis	Varies by cancer type and stage; generally better than older adults
Frequency	Approximately 70,000 cases per year in the United States
Deaths	Varies by cancer type; overall survival rates improving

Cancer in Adolescents and Young Adults (AYA) refers to the unique medical and psychosocial challenges faced by individuals diagnosed with cancer between the ages of 15 and 39. This age group experiences specific types of cancers and faces distinct challenges in diagnosis, treatment, and survivorship compared to younger children and older adults. The most common cancers in this group include leukemia, lymphoma, testicular cancer, breast cancer, and sarcomas.

Epidemiology

Cancer in AYAs is less common than in older adults but represents a significant burden due to the number of productive life years it affects. The incidence of cancer in this age group has been increasing over the past few decades for reasons that are not entirely understood. Despite this increase, survival rates have also improved due to advances in cancer treatment and supportive care.

Diagnosis

Diagnosing cancer in AYAs can be challenging. Symptoms often mimic those of more common, less serious conditions, leading to delays in diagnosis. Furthermore, AYAs may lack access to regular healthcare, making it less likely for them to seek help early. Awareness campaigns and education for both healthcare providers and the public are crucial to improving early diagnosis rates.

Treatment

Treatment for AYAs with cancer often requires a multidisciplinary approach, including medical oncology, surgical oncology, and radiation oncology. The unique biological characteristics of cancers in this age group, as well as the patients' developmental stage, necessitate tailored treatment protocols. Fertility preservation is an important consideration, as many cancer treatments can affect fertility.

Psychosocial Aspects

The diagnosis of cancer in AYAs can have profound psychosocial impacts. Issues such as interruption of education or career, financial challenges, changes in physical appearance, and fertility concerns can significantly affect mental health. Support services, including counseling and peer support groups, are vital components of comprehensive cancer care for AYAs.

Survivorship

Survivorship care is an essential aspect of cancer care for AYAs, addressing the long-term effects of cancer and its treatment. This includes monitoring for secondary cancers, managing chronic health issues related to treatment, and providing support for psychosocial issues. Survivorship care plans should be individualized, taking into account the specific needs and experiences of AYA cancer survivors.

Research and Advocacy

Research into cancers affecting AYAs is growing, focusing on understanding the biological differences of cancers in this age group, improving treatment outcomes, and addressing the unique psychosocial needs of these patients. Advocacy efforts aim to increase awareness, improve access to specialized care, and support research funding for AYA cancers.

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