Canrenoic acid
A potassium-sparing diuretic drug
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Canrenoic acid is a pharmaceutical drug that acts as a potassium-sparing diuretic. It is primarily used in the treatment of conditions such as congestive heart failure, hypertension, and edema.
Pharmacology
Canrenoic acid is a prodrug of canrenone, which is an active metabolite. It works by antagonizing the effects of aldosterone, a hormone that promotes the retention of sodium and water in the body. By inhibiting aldosterone, canrenoic acid helps to increase the excretion of sodium and water while retaining potassium, thus acting as a diuretic.
Mechanism of Action
Canrenoic acid binds to the mineralocorticoid receptor in the kidney, preventing aldosterone from exerting its effects. This leads to increased excretion of sodium and water, while potassium is retained, which is beneficial in conditions where potassium loss is a concern.
Clinical Uses
Canrenoic acid is used in the management of:
- Congestive heart failure
- Hypertension
- Edema associated with liver cirrhosis or nephrotic syndrome
Side Effects
Common side effects of canrenoic acid include:
- Hyperkalemia (elevated potassium levels)
- Hyponatremia (low sodium levels)
- Gastrointestinal disturbances
Contraindications
Canrenoic acid should not be used in patients with:
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