Cardiac glycoside

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Cardiac Glycoside

Cardiac glycosides (pronounced: kahr-dee-ak glahy-kuh-sahyd) are a class of organic compounds that have a direct effect on the heart, increasing its output force and reducing its rate of contractions by acting on the cellular sodium-potassium ATPase pump.

Etymology

The term "Cardiac glycoside" is derived from the Greek words "kardia" meaning heart, and "glykos" meaning sweet. This is due to the fact that these compounds have a direct effect on the heart and are sugar derivatives.

Related Terms

  • Digitalis: A genus of about 20 species of herbaceous perennials, shrubs, and biennials that are commonly used to produce cardiac glycosides.
  • Digoxin: A cardiac glycoside that is derived from the leaves of the digitalis plant. It is used to treat heart conditions such as congestive heart failure and atrial fibrillation.
  • Ouabain: A cardiac glycoside that is found naturally in a number of plants and animals. It is used in scientific research due to its ability to inhibit the sodium-potassium ATPase pump.
  • Sodium-potassium ATPase pump: An enzyme found in the plasma membrane of all animal cells. It is responsible for maintaining the cell's resting potential, and its inhibition by cardiac glycosides leads to increased force of heart contractions.

See Also

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