Epoetin gamma
Detailed article on Epoetin gamma
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Epoetin gamma is a recombinant DNA-derived form of erythropoietin, a glycoprotein hormone that regulates erythropoiesis (red blood cell production). It is used primarily in the treatment of anemia associated with chronic kidney disease and certain types of cancer.
Mechanism of Action
Epoetin gamma functions by stimulating the division and differentiation of committed erythroid progenitor cells in the bone marrow. It binds to the erythropoietin receptor on the surface of these progenitor cells, activating intracellular signaling pathways that lead to increased red blood cell production. This process is crucial for maintaining adequate oxygen transport in the body.
Clinical Uses
Epoetin gamma is indicated for the treatment of:
- Anemia due to chronic kidney disease in patients on dialysis and not on dialysis.
- Anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitantly administered chemotherapy.
Administration and Dosage
Epoetin gamma is administered via subcutaneous or intravenous injection. The dosage and frequency depend on the patient's condition, hemoglobin levels, and response to treatment. Regular monitoring of hemoglobin levels is essential to adjust the dose and avoid complications such as hypertension and thrombosis.
Side Effects
Common side effects of epoetin gamma include:
- Hypertension
- Headache
- Joint pain
- Fever
- Nausea
Serious side effects may include:
- Increased risk of thromboembolic events
- Pure red cell aplasia (rare)
Pharmacokinetics
Epoetin gamma has a similar pharmacokinetic profile to endogenous erythropoietin. It is primarily metabolized in the liver and excreted by the kidneys. The half-life of epoetin gamma varies depending on the route of administration, with intravenous administration having a shorter half-life compared to subcutaneous administration.
Regulatory Status
Epoetin gamma is approved for use in several countries and is subject to regulation by agencies such as the European Medicines Agency (EMA) and the U.S. Food and Drug Administration (FDA).
Research and Development
Ongoing research is focused on optimizing the efficacy and safety of epoetin gamma, as well as exploring its use in other conditions associated with anemia.
Also see
Template:Erythropoiesis-stimulating agents Template:Anemia treatment
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