Gorham's disease
Gorham's Disease
Gorham's disease (pronunciation: /ˈɡɔːrəmz diːˈziːz/), also known as Gorham-Stout syndrome or vanishing bone disease, is a rare bone disease characterized by the uncontrolled proliferation of lymphatic vessels that results in the progressive destruction of bone matter.
Etymology
The disease is named after the American doctor, Dr. Jackson W. Gorham, who first described the condition in detail in 1955. The term "Stout" refers to Dr. Arthur Purdy Stout, a pathologist who also studied the disease. The term "vanishing bone disease" is a descriptive term based on the disease's unique characteristic of causing bone to disappear.
Symptoms
The symptoms of Gorham's disease can vary greatly depending on the bones affected. Common symptoms include pain, swelling, and weakness in the affected area. In severe cases, when the disease affects the ribs or spine, it can lead to life-threatening complications such as pleural effusion or spinal cord compression.
Diagnosis
Diagnosis of Gorham's disease is often challenging due to its rarity and the lack of specific diagnostic criteria. It is typically identified through a combination of radiographic imaging, histopathological examination, and the exclusion of other diseases.
Treatment
There is currently no cure for Gorham's disease, and treatment is primarily aimed at managing symptoms and preventing complications. Treatment options may include surgery, radiation therapy, and medication such as bisphosphonates.
Prognosis
The prognosis for individuals with Gorham's disease varies widely. Some individuals may experience a halt in the progression of the disease, while others may experience continuous bone loss. The prognosis is generally poorer when the disease involves the spine or chest.
See also
External links
- Medical encyclopedia article on Gorham's disease
- Wikipedia's article - Gorham's disease
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