Indisetron

A detailed overview of the antiemetic drug Indisetron

Indisetron

Chemical structure of Indisetron

Indisetron is a pharmaceutical drug used primarily as an antiemetic to prevent nausea and vomiting associated with chemotherapy and radiotherapy. It belongs to the class of 5-HT3 receptor antagonists, which work by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

Mechanism of Action

Indisetron functions by selectively inhibiting the 5-HT3 receptors located in the central nervous system and the gastrointestinal tract. By blocking these receptors, Indisetron prevents the binding of serotonin, thereby reducing the occurrence of nausea and vomiting. This mechanism is particularly effective in managing chemotherapy-induced nausea and vomiting (CINV).

Pharmacokinetics

Indisetron is administered orally or intravenously. After administration, it is rapidly absorbed and distributed throughout the body. The drug undergoes hepatic metabolism and is primarily excreted via the kidneys. The half-life of Indisetron allows for convenient dosing schedules, often aligning with chemotherapy sessions.

Clinical Uses

Indisetron is indicated for the prevention of:

• Chemotherapy-induced nausea and vomiting (CINV)
• Radiotherapy-induced nausea and vomiting
• Postoperative nausea and vomiting (PONV)

Side Effects

Common side effects of Indisetron include:

• Headache
• Constipation
• Dizziness
• Fatigue

Less common but serious side effects may include:

• Allergic reactions
• QT interval prolongation

Contraindications

Indisetron should not be used in patients with known hypersensitivity to the drug or any of its components. Caution is advised in patients with a history of cardiac arrhythmias due to the potential for QT interval prolongation.

Related pages

• 5-HT3 receptor antagonist
• Chemotherapy-induced nausea and vomiting
• Serotonin
• Pharmacology