Netilmicin

Netilmicin

Netilmicin (pronounced: net-il-MY-sin) is an aminoglycoside antibiotic used primarily in the treatment of infections caused by Gram-negative bacteria. It is derived from the antibiotic sisomicin through chemical modifications.

Etymology

The term "Netilmicin" is derived from the Italian company Nettuno, which first synthesized the drug, and Micin, a common suffix for aminoglycoside antibiotics.

Pharmacology

Netilmicin works by binding to the 30S ribosomal subunit of the bacterial cell, inhibiting protein synthesis and leading to cell death. It is particularly effective against Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae.

Usage

Netilmicin is used in the treatment of severe infections, including sepsis, respiratory tract infections, urinary tract infections, and intra-abdominal infections. It is often used in combination with other antibiotics for a synergistic effect.

Side Effects

Like other aminoglycosides, netilmicin can cause nephrotoxicity and ototoxicity. Regular monitoring of kidney function and hearing is recommended during treatment.

Related Terms

• Aminoglycoside
• Antibiotic
• Gram-negative bacteria
• 30S ribosomal subunit
• Protein synthesis
• Pseudomonas aeruginosa
• Escherichia coli
• Klebsiella pneumoniae
• Sepsis
• Respiratory tract infections
• Urinary tract infections
• Intra-abdominal infections
• Nephrotoxicity
• Ototoxicity

External links

• Medical encyclopedia article on Netilmicin
• Wikipedia's article - Netilmicin

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