PDGFC

PDGFC (Platelet Derived Growth Factor C) is a protein that in humans is encoded by the PDGFC gene. This protein is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines.

Function

The PDGFC protein is a potent mitogen for cells of mesenchymal origin. It functions by binding to its receptor, PDGFR-α, and inducing its dimerization. This leads to the activation of the receptor's intrinsic tyrosine kinase activity, which in turn triggers a series of downstream signaling events. These events promote cell proliferation, survival, and migration, and they play a crucial role in the development and maintenance of several types of tissues.

Clinical significance

Mutations in the PDGFC gene have been associated with several types of cancer, including breast cancer, lung cancer, and glioblastoma. In addition, overexpression of PDGFC has been observed in a variety of tumors, suggesting that it may play a role in tumor growth and progression.

See also

• Platelet-derived growth factor
• PDGFR-α
• Cancer