POLE4
POLE4 is a gene that encodes the DNA polymerase epsilon 4, accessory subunit in humans. This gene is part of the larger DNA polymerase family, which is responsible for DNA replication and repair. The POLE4 protein is one of four subunits that make up the DNA polymerase epsilon complex, which plays a critical role in DNA replication and DNA repair.
Function
The POLE4 protein is a small, non-catalytic accessory subunit of the DNA polymerase epsilon complex. This complex is involved in DNA replication and repair, and is essential for the survival of the cell. The POLE4 subunit is thought to enhance the processivity of the DNA polymerase epsilon complex and may also play a role in coordinating the activities of the other subunits.
Clinical Significance
Mutations in the POLE4 gene have been associated with a variety of cancers, including colorectal cancer, endometrial cancer, and ovarian cancer. These mutations can lead to an increased rate of DNA replication errors, which can contribute to the development and progression of cancer.
Research
Research into the POLE4 gene and its associated protein is ongoing. Understanding the function of this gene and its role in DNA replication and repair could lead to new treatments for cancer and other diseases associated with DNA damage.
See Also
References
| Genes on human chromosome 12 | ||||
|---|---|---|---|---|
This human chromosome 12 related article is a stub.
|
| DNA replication (comparing prokaryotic to eukaryotic) | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| DNA repair | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
* Category
|
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
