S1PR4
S1PR4
S1PR4 (Sphingosine-1-phosphate receptor 4) is a G protein-coupled receptor that binds the lipid signaling molecule sphingosine-1-phosphate (S1P). This receptor is part of the sphingosine-1-phosphate receptor family, which plays a crucial role in the regulation of various physiological processes, including immune system function and cardiovascular development.
Function
S1PR4 is primarily expressed in lymphoid tissue and is involved in the modulation of immune cell trafficking and function. It is known to influence the behavior of T cells, B cells, and natural killer cells. The receptor's activity is mediated by its interaction with intracellular G proteins, which transduce signals to downstream effectors, influencing cell migration, proliferation, and survival.
Clinical Significance
Alterations in S1PR4 signaling have been implicated in various disease states, including autoimmune disorders and cancer. The receptor is a potential target for therapeutic intervention in conditions where immune cell regulation is disrupted.
Research
Recent studies have focused on the role of S1PR4 in inflammatory diseases and its potential as a biomarker for disease progression. The development of selective S1PR4 agonists and antagonists is an area of active research, aiming to modulate immune responses in a controlled manner.
See Also
References
External Links
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