SIRPG

SIRPG (Signal Regulatory Protein Gamma) is a protein that in humans is encoded by the SIRPG gene. It is a member of the signal regulatory protein (SIRP) family, and also known as CD172g. SIRPG is involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.

Function

The SIRPG protein is a receptor present on the surface of T cells, natural killer cells, and myeloid cells. It interacts with CD47 (a protein found on the surface of many cell types) to prevent the cells from being phagocytosed. This interaction is a critical part of the immune response, as it helps to regulate the body's response to both self and foreign cells.

Clinical significance

Alterations in the SIRPG gene have been associated with susceptibility to autoimmune diseases, including rheumatoid arthritis and type 1 diabetes. In addition, SIRPG has been implicated in the progression of certain types of cancer, including leukemia and lymphoma.

Research

Research into the role of SIRPG in the immune response and disease progression is ongoing. Current areas of focus include the potential for targeting the SIRPG-CD47 interaction in the treatment of cancer and autoimmune diseases.

See also

• Signal regulatory protein
• CD47
• Immune response
• Autoimmune diseases
• Cancer

References

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