Segesterone acetate/ethinylestradiol

From WikiMD's medical encyclopedia

Segesterone Acetate/Ethinylestradiol is a contraceptive vaginal system (CVS) used for the prevention of pregnancy. It is a combination of two hormones, segesterone acetate and ethinylestradiol, which work together to prevent ovulation and alter the cervical mucus and endometrium.

Etymology

The name "Segesterone Acetate/Ethinylestradiol" is derived from the two active ingredients in the contraceptive. "Segesterone" is a progestin hormone, "acetate" refers to the ester form of the hormone, and "ethinylestradiol" is a synthetic form of estrogen.

Mechanism of Action

Segesterone acetate is a progestin that inhibits the secretion of gonadotropins, which in turn prevents follicular maturation and ovulation. Ethinylestradiol enhances the contraceptive effect by suppressing follicle-stimulating hormone (FSH) and luteinizing hormone (LH), thereby inhibiting ovulation. It also alters the cervical mucus to inhibit sperm penetration and changes the endometrium to reduce the likelihood of implantation.

Usage

The Segesterone Acetate/Ethinylestradiol CVS is a flexible ring that is inserted into the vagina and left in place for 21 days, followed by a 7-day ring-free period. It is designed to be used continuously, with a new ring inserted at the end of each ring-free week.

Side Effects

Common side effects include headache, nausea, vomiting, abdominal pain, breast tenderness, and menstrual irregularities. Serious side effects may include blood clots, stroke, and heart attack.

Related Terms

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Contributors: Prab R. Tumpati, MD