Formyl peptide receptor 2

Formyl peptide receptor 2 (FPR2), also known as ALX or FPRL1, is a protein that in humans is encoded by the FPR2 gene. This protein is a member of the G protein-coupled receptor family, and plays a crucial role in the immune system and inflammation response.

Structure

The FPR2 protein is a cell surface receptor that is predominantly expressed in immune cells such as neutrophils, monocytes, and macrophages. It is a seven-transmembrane domain receptor, which is a characteristic feature of G protein-coupled receptors.

Function

FPR2 is involved in the regulation of several key functions of the immune system. It is activated by a variety of ligands, including lipoxin A4 and serum amyloid A. Upon activation, FPR2 triggers a series of intracellular signaling pathways that lead to various immune responses, such as chemotaxis, phagocytosis, and the production of reactive oxygen species.

Clinical significance

Alterations in the function or expression of FPR2 have been implicated in a variety of diseases, including chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, and Alzheimer's disease. Therefore, FPR2 is considered a potential therapeutic target for these conditions.

Research

Research on FPR2 is ongoing, with studies focusing on understanding its role in the immune system and its potential as a therapeutic target. Some studies are investigating the use of FPR2 agonists and antagonists in the treatment of inflammatory diseases.

See also

• Formyl peptide receptor
• G protein-coupled receptor
• Immune system
• Inflammation

References

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