Osilodrostat
Osilodrostat (pronounced as oh-si-lo-DROH-stat) is a medication used in the treatment of Cushing's syndrome, a condition characterized by an excess of the hormone cortisol in the body. It is marketed under the brand name Isturisa.
Etymology
The name "Osilodrostat" is derived from its chemical structure and its function. The prefix "Osilo-" is derived from its chemical class, while "-drostat" indicates its function as a cortisol synthesis inhibitor.
Pharmacology
Osilodrostat works by inhibiting the enzyme 11β-hydroxylase, which is involved in the final step of cortisol synthesis in the adrenal glands. By blocking this enzyme, osilodrostat reduces the production of cortisol.
Usage
Osilodrostat is used in adults with Cushing's syndrome for whom surgery is not an option or has not been successful. It is taken orally, usually twice a day.
Side Effects
Common side effects of osilodrostat include nausea, headache, fatigue, and adrenal insufficiency. In rare cases, it can cause abnormal heart rhythms.
Related Terms
See Also
External links
- Medical encyclopedia article on Osilodrostat
- Wikipedia's article - Osilodrostat
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