5-FU
5-Fluorouracil (5-FU)
5-Fluorouracil (also known as 5-FU) is a chemotherapy drug used in the treatment of various types of cancer. It belongs to a class of drugs known as antimetabolites and works by interfering with the growth of cancer cells.
Uses
5-FU is used to treat several types of cancer, including colorectal cancer, breast cancer, stomach cancer, esophageal cancer, and pancreatic cancer. It is often used in combination with other chemotherapy drugs to enhance its effectiveness.
Mechanism of Action
5-FU works by inhibiting the enzyme thymidylate synthase, which is necessary for the synthesis of DNA. By blocking this enzyme, 5-FU prevents cancer cells from replicating and growing.
Side Effects
Common side effects of 5-FU include nausea, vomiting, diarrhea, and mouth sores. More serious side effects can include neutropenia (low white blood cell count), thrombocytopenia (low platelet count), and anemia (low red blood cell count).
Contraindications
5-FU should not be used in patients with known hypersensitivity to fluorouracil or any component of the formulation. It is also contraindicated in patients with severe leukopenia, thrombocytopenia, or severe anemia.
Interactions
5-FU can interact with several other medications, including warfarin, phenytoin, and leucovorin. It is important for patients to inform their healthcare provider of all medications they are currently taking.
See Also
External links
- Medical encyclopedia article on 5-FU
- Wikipedia's article - 5-FU
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