Abatacept
Abatacept (pronounced as ah-buh-TAY-sept) is a medication used in the treatment of certain autoimmune diseases, such as Rheumatoid Arthritis and Juvenile Idiopathic Arthritis.
Etymology
The name "Abatacept" is derived from the Latin roots "aba-" meaning "away from", and "-cept" meaning "taken". This refers to the drug's function of inhibiting the activation of T-cells, a type of white blood cell that plays a key role in the body's immune response.
Pharmacology
Abatacept is a selective costimulation modulator as it inhibits the costimulation of T cells. It is a fusion protein composed of the Fc region of the immunoglobulin IgG1 fused to the extracellular domain of CTLA-4, a molecule capable of binding to CD80 and CD86 on antigen-presenting cells.
Usage
Abatacept is used to treat moderate to severe rheumatoid arthritis in adults and children who have had an inadequate response to one or more Disease-Modifying Antirheumatic Drugs (DMARDs). It is also used in the treatment of psoriatic arthritis and to prevent organ rejection in kidney transplant patients.
Side Effects
Common side effects of Abatacept include headache, nausea, and infections. Serious side effects may include severe infections, malignancies, and hypersensitivity reactions.
Related Terms
- Rheumatoid Arthritis
- Juvenile Idiopathic Arthritis
- CD80
- CD86
- Disease-Modifying Antirheumatic Drugs (DMARDs)
External links
- Medical encyclopedia article on Abatacept
- Wikipedia's article - Abatacept
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