Mycophenolic acid
Mycophenolic acid
Mycophenolic acid (pronunciation: my-co-fen-oh-lic acid) is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), an enzyme that plays a key role in the proliferation of B cells and T cells.
Etymology
The term "Mycophenolic acid" is derived from Penicillium brevicompactum, a species of fungus from which it was first isolated in 1896. The prefix "myco-" comes from the Greek word "mykes" meaning fungus, and "phenolic" refers to the presence of a phenol functional group in the chemical structure of the compound.
Usage
Mycophenolic acid is primarily used as an immunosuppressive drug in organ transplantation to prevent rejection. It is also used in the treatment of autoimmune diseases such as lupus, rheumatoid arthritis, and psoriasis.
Related Terms
- Mycophenolate mofetil: A prodrug of mycophenolic acid used in organ transplantation.
- Inosine monophosphate dehydrogenase: The enzyme inhibited by mycophenolic acid.
- Immunosuppressive drug: A class of drugs that reduce the strength of the body's immune system, including mycophenolic acid.
See Also
External links
- Medical encyclopedia article on Mycophenolic acid
- Wikipedia's article - Mycophenolic acid
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