Ames test

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Ames test

The Ames test is a biological assay used to assess the mutagenic potential of chemical compounds. Named after its developer, Bruce Ames, the test serves as a quick and relatively inexpensive way to gauge the carcinogenic risk of a substance.

Pronunciation

  • IPA: /eɪmz tɛst/

Etymology

The test is named after its inventor, Bruce Ames, an American biochemist and molecular biologist.

Procedure

The Ames test uses several strains of the bacterium Salmonella typhimurium that carry mutations in genes involved in histidine synthesis. These strains are unable to synthesize the essential amino acid histidine unless a new mutation occurs, allowing them to regain this ability. The test compound is mixed with the bacteria and incubated. If the number of colonies observed is significantly higher than a control sample, the compound is considered mutagenic and, therefore, a potential carcinogen.

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