Euthyroid sick syndrome

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Euthyroid Sick Syndrome

Euthyroid sick syndrome (pronounced: yoo-thy-roid sick sin-drome), also known as non-thyroidal illness syndrome or low T3 syndrome, is a condition characterized by abnormal thyroid hormone levels in the absence of thyroid illness.

Etymology

The term "euthyroid" is derived from the Greek words "eu" meaning good or normal, and "thyroid" meaning shield, referring to the normal functioning of the thyroid gland. "Sick syndrome" refers to the abnormal thyroid hormone levels seen in critically ill patients.

Definition

Euthyroid sick syndrome is a state of adaptation or dysregulation of thyrotropic feedback control wherein the levels of T3 and/or T4 are abnormal, but the thyroid gland does not appear to be dysfunctional. This condition occurs in patients with starvation, critical illness, or other forms of stress.

Symptoms

Symptoms of euthyroid sick syndrome are often subtle and non-specific, and may include fatigue, weight loss, and depression. These symptoms are often attributed to the underlying illness rather than to a thyroid disorder.

Diagnosis

Diagnosis of euthyroid sick syndrome is based on the presence of low serum T3 and/or T4 levels in the absence of thyroid disease. Other diagnostic tests may include a TSH test and a rT3 test.

Treatment

Treatment of euthyroid sick syndrome is primarily focused on managing the underlying illness. In some cases, thyroid hormone replacement therapy may be used.

Related Terms

External links

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