Miltefosine
Miltefosine
Miltefosine (pronounced as mil-te-fo-seen) is an antiparasitic drug used in the treatment of leishmaniasis, a disease caused by parasites of the genus Leishmania.
Etymology
The term "Miltefosine" is derived from its chemical structure, which is a phosphocholine derivative. The "milte" part of the name is an arbitrary designation, while "fosine" refers to its phosphocholine nature.
Usage
Miltefosine is primarily used to treat cutaneous leishmaniasis, mucocutaneous leishmaniasis, and visceral leishmaniasis, which are all caused by different species of the Leishmania parasite. It is also used to treat free-living amoeba infections.
Mechanism of Action
Miltefosine works by disrupting the cell membrane of the Leishmania parasite, leading to its death. It is thought to inhibit the enzyme phosphatidylcholine biosynthesis, which is crucial for the parasite's survival.
Side Effects
Common side effects of miltefosine include nausea, vomiting, diarrhea, and abdominal pain. More serious side effects may include kidney problems, liver problems, and severe allergic reactions.
Related Terms
- Antiparasitic: A type of drug used to treat parasitic infections.
- Leishmaniasis: A disease caused by parasites of the genus Leishmania.
- Phosphatidylcholine biosynthesis: An enzyme crucial for the survival of the Leishmania parasite.
External links
- Medical encyclopedia article on Miltefosine
- Wikipedia's article - Miltefosine
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