Parecoxib

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Parecoxib

Parecoxib (pronounced: par-eh-COX-ib) is a nonsteroidal anti-inflammatory drug (NSAID) that is primarily used in the management of acute pain. It is a prodrug of valdecoxib, meaning it is metabolically converted into the active drug valdecoxib in the body.

Etymology

The name "Parecoxib" is derived from its parent drug, valdecoxib. The prefix "par-" is a common prefix in pharmacology, often used to indicate a derivative or variant of a parent compound.

Pharmacology

Parecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. This means it specifically inhibits the COX-2 enzyme, reducing the production of prostaglandins, which are chemicals that cause inflammation, pain, and fever in the body. By inhibiting COX-2, parecoxib helps to reduce these symptoms.

Clinical Use

Parecoxib is used for the short-term treatment of postoperative pain. It is administered intravenously or intramuscularly. The drug is particularly useful in patients who cannot take oral medications or in situations where oral medications may not be effective.

Side Effects

Like other NSAIDs, parecoxib can cause a range of side effects. These can include gastrointestinal problems such as stomach ulcers and bleeding, as well as cardiovascular issues such as heart attack and stroke. It can also cause skin reactions and kidney problems.

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