What is Tucatinib?
- Tucatinib TUKYSA is a kinase inhibitor indicated in combination with trastuzumab and capecitabine for treatment of adult patients with advanced unresectable or metastatic HER2-positive breast cancer.
What are the uses of this medicine?
- human epidermal growth factor receptor-2 (HER2) positive breast cancer that has spread to other parts of the body such as the brain (metastatic), or that cannot be removed by surgery, and
- who have received one or more anti-HER2 breast cancer treatments.
How does this medicine work?
- Tucatinib An orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity.
- Tucatinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells.
- ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.
Who Should Not Use this medicine ?
- This medicine have no usage limitations.
What drug interactions can this medicine cause?
Avoid concomitant use with :
- strong CYP3A inducers or moderate CYP2C8 inducers.
- Strong CYP2C8 Inhibitors
- CYP3A Substrates
- P-gp Substrates
Is this medicine FDA approved?
- It was approved for use in the United States in 2020.
How should this medicine be used?
- The recommended dosage of TUKYSA is 300 mg taken orally twice daily in combination with trastuzumab and capecitabine until disease progression or unacceptable toxicity.
- For patients with severe hepatic impairment, the recommended dosage is 200 mg orally twice daily.
- Take TUKYSA exactly as your healthcare provider tells you.
- TUKYSA is used with the medicines trastuzumab and capecitabine. Your healthcare provider will tell you the dose of trastuzumab and capecitabine you will take and how you will receive them.
- Take TUKYSA 2 times a day, with or without a meal.
- Take TUKYSA about 12 hours apart or at the same times every day.
- Swallow TUKYSA tablets whole. Do not chew, crush, or split TUKYSA tablets before swallowing. Do not take TUKYSA tablets if they are broken, cracked, or damaged.
- If you vomit or miss a dose of TUKYSA, take your next dose at your regular time.
What are the dosage forms and brand names of this medicine?
This medicine is available in fallowing doasage form:
- As Tablets: 50 mg and 150 mg
This medicine is available in fallowing brand namesː
What side effects can this medication cause?
Common possible side effects and laboratory abnormalities of this medicine include:
- rash, redness, pain, swelling or blisters on the palms of your hands or soles of your feet
- increased liver function blood tests
- mouth sores (stomatitis)
- decreased appetite
- stomach-area (abdomen) pain
- low red blood cell counts (anemia)
TUKYSA may cause serious side effects, including:
- Diarrhea: Diarrhea is common with TUKYSA and can sometimes be severe.
- Liver Problems: TUKYSA can cause severe liver problems.
What special precautions should I follow?
- Severe diarrhea, including dehydration, acute kidney injury, and death, has been reported. Administer antidiarrheal treatment as clinically indicated. Interrupt dose, then dose reduce, or permanently discontinue TUKYSA based on severity.
- Severe hepatotoxicity has been reported on TUKYSA. Monitor ALT, AST and bilirubin prior to starting TUKYSA, every 3 weeks during treatment and as clinically indicated. Interrupt dose, then dose reduce, or permanently discontinue TUKYSA based on severity.
- TUKYSA can cause fetal harm. Advise patients of potential risk to a fetus and to use effective contraception.
What to do in case of emergency/overdose?
- In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.
- Overdose related information is also available online at poisonhelp.org/help.
- In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.
Can this medicine be used in pregnancy?
- TUKYSA can cause fetal harm when administered to a pregnant woman.
- There are no available human data on TUKYSA use in pregnant women to inform a drug-associated risk.
Can this medicine be used in children?
- The safety and effectiveness of TUKYSA in pediatric patients have not been established.
What should I know about storage and disposal of this medication?
- Store at controlled room temperature, 20ºC to 25ºC (68ºF to 77ºF); excursions permitted from 15ºC to 30ºC (59ºF to 86ºF) .
- Dispense to patient in original container only. Store in original container to protect from moisture.
- Replace cap securely each time after opening. Do not discard desiccant.
- Once opened, use within 3 months.
- Discard any unused tablets 3 months after opening the bottle.
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Learn more about Tucatinib
- Dailymed label info on Tucatinib
- Scientific articles
- Drug portal Tucatinib
- toxicity info on Tucatinib
- FDA Tucatinib