Ketanserin
Ketanserin is a serotonin antagonist drug that is primarily used in the treatment of hypertension. It was first synthesized in the 1980s by the pharmaceutical company Janssen Pharmaceutica.
Pharmacology
Ketanserin is classified as a serotonin receptor antagonist, specifically targeting the 5-HT2A receptor. It works by blocking the action of serotonin, a neurotransmitter that can cause blood vessels to narrow and blood pressure to increase. By blocking the action of serotonin, ketanserin helps to relax and widen blood vessels, thereby reducing blood pressure.
Clinical Uses
The primary use of ketanserin is in the treatment of hypertension. It is particularly effective in patients who have not responded well to other antihypertensive drugs. In addition to its antihypertensive effects, ketanserin has also been found to have beneficial effects in the treatment of certain psychiatric disorders, such as schizophrenia and depression, due to its ability to block the 5-HT2A receptor.
Side Effects
Like all drugs, ketanserin can cause side effects. The most common side effects include dizziness, headache, and dry mouth. Less common side effects can include nausea, fatigue, and palpitations. In rare cases, ketanserin can cause serious side effects such as abnormal heart rhythms and low blood pressure.
Research
Research into the potential uses of ketanserin is ongoing. Recent studies have suggested that it may have potential as a treatment for certain types of cancer, due to its ability to inhibit the growth of cancer cells. However, more research is needed to confirm these findings.
See Also
| Serotonin receptor modulators | ||||||
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| Antihypertensive agents | ||||||||||
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This antihypertensive agent related article is a stub.
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