Lomitapide
Lomitapide
Lomitapide (pronounced loh-MIT-uh-pide) is a medication used in the treatment of homozygous familial hypercholesterolemia (HoFH), a rare genetic disorder that leads to severe elevated cholesterol levels.
Etymology
The name 'Lomitapide' is derived from its chemical structure. However, the exact etymology is not known.
Usage
Lomitapide is used along with a low-fat diet and other treatments to lower total cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein B (apo B), and triglycerides in adults and children who are at least 10 years old with homozygous familial hypercholesterolemia.
Mechanism of Action
Lomitapide works by reducing the amount of cholesterol (a type of fat) in the body. It does this by blocking a protein called microsomal triglyceride transfer protein (MTP), which is involved in the production of very low-density lipoprotein (VLDL) in the liver and intestines. By inhibiting MTP, lomitapide decreases the production of VLDL, which in turn reduces the level of LDL cholesterol in the blood.
Side Effects
Common side effects of lomitapide include diarrhea, nausea, vomiting, stomach pain, and abnormal liver function tests. Serious side effects may include liver damage and severe diarrhea.
Related Terms
- Homozygous familial hypercholesterolemia
- Cholesterol
- Low-density lipoprotein
- Apolipoprotein B
- Triglycerides
- Microsomal triglyceride transfer protein
- Very low-density lipoprotein
External links
- Medical encyclopedia article on Lomitapide
- Wikipedia's article - Lomitapide
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski