Spindle poison
Other names
The term spindle poison is also known as a spindle toxin.
Definition
It is a poison that disrupts cell division by affecting the protein threads that connect the centromere regions of chromosomes, known as spindles.
Effects
Spindle poisons effectively cease the production of new cells by interrupting the mitosis phase of cell division at the spindle assembly checkpoint (SAC).
Limitations
However, Spindle poisons are not yet 100% effective at ending the formation of tumors (neoplasms).
Role in Chemotherapy
Although not 100% effective, substantive therapeutic efficacy has been found in these types of chemotherapeutic treatments.
Mitotic spindle
The mitotic spindle is composed of microtubules (polymerized tubulin) that aid, along with regulatory proteins; each other in the activity of appropriately segregating replicated chromosomes.
Example spindle poisons
- Examples of spindle poisons include paclitaxel and vinblastine
Other examples include:
- Mebendazole
- Colchicine
- Griseofulvin
- [[Vinca alkaloid
Mechanism of action
- They exert their potent anti-neoplastic effects through activation of the spindle assembly checkpoint (SAC), thus arresting cells in mitosis.
Non-responders
- Unfortunately, only certain cancers are susceptible to these drugs, and many patients fail to respond to treatment.
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