Duloxetine

Duloxetine chemical structure

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Duloxetine hydrochloride 3D structure

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Duloxetine (SNRI) packaging

Cymbalta 60mg capsule

Duloxetine is a type of antidepressant medication that is classified as a serotonin-norepinephrine reuptake inhibitor (SNRI). It is primarily used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), fibromyalgia, and neuropathic pain.

Pharmacology[edit]

Duloxetine works by inhibiting the reuptake of serotonin and norepinephrine, two neurotransmitters in the brain. This results in an increase in the concentration of these neurotransmitters in the synaptic cleft, which leads to enhanced neurotransmission.

Medical uses[edit]

Duloxetine is approved for the treatment of major depressive disorder, generalized anxiety disorder, fibromyalgia, and neuropathic pain. It is also used off-label for the treatment of stress urinary incontinence.

Side effects[edit]

Common side effects of duloxetine include nausea, dry mouth, drowsiness, and sweating. More serious side effects can include suicidal thoughts, liver damage, and serotonin syndrome.

Contraindications[edit]

Duloxetine should not be used in individuals with a known hypersensitivity to the drug. It is also contraindicated in individuals with uncontrolled glaucoma due to the risk of increased intraocular pressure.

Interactions[edit]

Duloxetine can interact with a number of other medications, including other antidepressants, monoamine oxidase inhibitors (MAOIs), and certain antibiotics. It is important to discuss all medications and supplements with a healthcare provider before starting duloxetine.