Complement receptor 1

Complement receptor 1 (CR1), also known as CD35 (Cluster of Differentiation 35), is a protein that in humans is encoded by the CR1 gene. It is involved in the immune system's response to disease and infection.

Pronunciation

The term is pronounced as /ˈkɒmplɪmənt/ /rɪˈsɛptər/ /wʌn/.

Etymology

The term "complement" in "complement receptor 1" comes from the fact that this protein complements the action of antibodies in destroying bacteria. The term "receptor" is derived from the Latin word "recipere", meaning "to receive", as it receives signals from other cells or molecules.

Function

Complement receptor 1 is a cell surface receptor that binds to complement fragments, particularly C3b and C4b, to mediate cellular responses, including phagocytosis and immune regulation. It is expressed on a variety of immune cells, including erythrocytes, leukocytes, and macrophages.

Clinical significance

Alterations in the CR1 gene have been associated with susceptibility to systemic lupus erythematosus (SLE), a chronic autoimmune disease. Additionally, the number of CR1 receptors on red blood cells can influence the severity of malaria, as the receptors can bind to the parasite Plasmodium falciparum.

Related terms

• Complement system
• Immune system
• Phagocytosis
• Systemic lupus erythematosus
• Malaria

External links

• Medical encyclopedia article on Complement receptor 1
• Wikipedia's article - Complement receptor 1

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