Fluclotizolam

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Fluclotizolam


Fluclotizolam is a thienotriazolodiazepine derivative which was first synthesized in 1979, but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified in 2017.

Chemistry

Fluclotizolam is a thienotriazolodiazepine, which is a group of benzodiazepine analogs. The thienotriazolodiazepine core of fluclotizolam is a combination of a thiophene ring fused with a triazolodiazepine ring. This core structure is shared with a number of other benzodiazepine drugs, including etizolam and brotizolam.

Pharmacology

Like other benzodiazepines, fluclotizolam acts as a positive allosteric modulator of the GABA_A receptor, enhancing the effects of the neurotransmitter GABA. This results in sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant effects.

Effects

The effects of fluclotizolam are similar to other benzodiazepines, such as anxiolysis, disinhibition, lethargy, muscle relaxation, and euphoria. However, due to its potency, it also has a high potential for abuse and can cause severe physical dependence and withdrawal symptoms.

Legal Status

The legal status of fluclotizolam varies by country. In some countries, it is a controlled substance, while in others it is legal to possess for personal use.

See Also


GABA receptor modulators
Ionotropic
GABAA
* Agonists: (+)-Catechin
GABAA-ρ
Metabotropic


Sedatives and Hypnotics

Miscellaneous Agents

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Contributors: Prab R. Tumpati, MD