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Ibuprofen (I-byoo-PROH-fen)A drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID). Also called Advil and Motrin.

Information about Ibuprofen

Ibuprofen is a commonly used nonsteroidal antiinflammatory (NSAID) drug which is available both by prescription and over-the-counter. 


Liver safety of Ibuprofen

Ibuprofen is considered to be among the safest NSAIDs and is generally well tolerated but can, nevertheless, rarely cause clinically apparent and serious acute liver injury.

Mechanism of action of Ibuprofen

Ibuprofen (eye" bue proe' fen) is a propionic acid NSAID similar to ketoprofen and naproxen.  Like other NSAIDs, ibuprofen is a potent inhibitor of cellular cyclooxygenases (Cox-1 and Cox-2) which blocks the formation of prostaglandin, prostacyclin and thromboxane products, important mediators of inflammation and pain. 

FDA approval information for Ibuprofen

Ibuprofen has analgesic as well as antipyretic and antiinflammatory activities.  Ibuprofen was approved for use by prescription in the United States in 1974 and was made available over-the-counter in 1984.  Currently, more than 20 million prescriptions for ibuprofen are filled yearly, a number that does not include its vast over-the-counter use.  Ibuprofen is used for treatment of mild-to-moderate forms of joint pain and arthritis from trauma, osteoarthritis or rheumatoid arthritis.  Ibuprofen is also active against other forms of pain including headache and dysmenorrhea. 

Dosage and administration for Ibuprofen

The recommended dose for chronic arthritis in adults is 400 to 800 mg orally three to four times daily, whereas intermittent dosing with lesser amounts is used for headache and pain.  Ibuprofen is available both by prescription and over-the-counter in multiple generic formulations, either alone or in combination with other analgesics, antihistamines or anticholinergic agents usually in doses of 200, 400, 600, or 800 mg.  Pediatric formulations are also available. 

Brand name for Ibuprofen

Common brand names for ibuprofen include Advil, Motrin, Nuprin, Rufen and Trendar.  Ibuprofen is also found in many combination formulations for dysmenorrhea, headache, allergies, upper respiratory tract symptoms and other pain syndromes under names such as Dristan, Haltran, and Aches-N-Pain. 

Side effects of Ibuprofen

Side effects are not common, but may include headache, dizziness, somnolence, dyspepsia, nausea, abdominal discomfort, heartburn, diarrhea, peripheral edema and hypersensitivity reactions.

Nonsteroidal Antiinflammatory Drugs (NSAIDs)

Acetaminophen, Celecoxib, Diclofenac, Diflunisal, Etodolac, Fenoprofen, Flurbiprofen, Ibuprofen, Indomethacin, Ketoprofen, Ketorolac, Mefenamic Acid, Meloxicam, Nabumetone, Naproxen, Nimesulide, Oxaprozin, Phenylbutazone, Piroxicam, Rofecoxib, Sulindac, Tolmetin

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