Naldemedine
Naldemedine (pronounced: nal-de-MED-een) is a medication used in the treatment of opioid-induced constipation (OIC). It is a peripherally acting mu-opioid receptor antagonist (PAMORA) that functions by blocking the binding of opioids to the mu-opioid receptors in the gastrointestinal tract.
Etymology
The name "Naldemedine" is derived from the chemical structure of the drug, which is a derivative of naltrexone. The "-medine" suffix is common in drugs that act on the opioid receptors.
Pharmacology
Naldemedine works by blocking the binding of opioids to the mu-opioid receptors in the gastrointestinal tract. This prevents the constipating effects of opioids without affecting their analgesic effects in the central nervous system.
Clinical Use
Naldemedine is used for the treatment of OIC in adult patients with chronic non-cancer pain. It is also used in patients with chronic pain related to prior cancer or its treatment who do not require frequent opioid dosage escalation.
Side Effects
Common side effects of Naldemedine include stomach pain, diarrhea, nausea, and vomiting. Serious side effects may include symptoms of opioid withdrawal in patients who have been on long-term opioids.
Related Terms
External links
- Medical encyclopedia article on Naldemedine
- Wikipedia's article - Naldemedine
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