Perampanel

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Perampanel

Perampanel (pronunciation: /pɛrˈæmpænɛl/) is a non-competitive AMPA receptor antagonist that is used primarily in the treatment of epilepsy. It is marketed under the brand name Fycompa.

Etymology

The term "Perampanel" is derived from the chemical name 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile. The name is a portmanteau of parts of the chemical name.

Usage

Perampanel is used as an adjunctive therapy in the treatment of partial-onset seizures and primary generalized tonic-clonic seizures in patients with epilepsy. It is also used for the treatment of seizures associated with Lennox-Gastaut syndrome in patients 12 years of age and older.

Mechanism of Action

Perampanel selectively antagonizes the action of glutamate at the AMPA receptor, thereby reducing neuronal excitation. This action is believed to contribute to its efficacy in treating seizures.

Side Effects

Common side effects of Perampanel include dizziness, fatigue, irritability, falls, nausea, weight gain, vertigo, and ataxia. Serious side effects may include aggression, anger, and suicidal thoughts or behaviors.

Related Terms

External links

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