Cefotaxime

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Cefotaxime

Cefotaxime (pronounced: sef-oh-TAKS-eem) is a third-generation Cephalosporin antibiotic. It is used to treat a variety of bacterial infections, particularly those caused by Gram-negative bacteria.

Etymology

The term "Cefotaxime" is derived from the Greek words "kephale" meaning "head" and "taxi" meaning "order". The "-ime" suffix is common in many antibiotics, indicating its role in fighting against bacterial infections.

Usage

Cefotaxime is used to treat a wide range of infections, including those of the skin, bones, joints, urinary tract, respiratory tract, and abdominal infections. It is also used to treat meningitis, gonorrhea, and septicemia.

Mechanism of Action

Cefotaxime works by inhibiting the synthesis of the bacterial cell wall, leading to cell death. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, inhibiting the cross-linking of the peptidoglycan structure, which is necessary for the bacteria's survival.

Side Effects

Common side effects of Cefotaxime include diarrhea, nausea, vomiting, rash, and pain or inflammation at the injection site. Severe side effects may include Clostridium difficile associated diarrhea, allergic reactions, and seizures.

Related Terms

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