18-Methoxycoronaridine

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18-Methoxycoronaridine

18-Methoxycoronaridine (pronunciation: 18-Me-thoxy-co-ro-na-ri-dine) is a synthetic organic compound that is used in the field of neuroscience to study addiction. It is a derivative of ibogaine, a naturally occurring alkaloid found in the Tabernanthe iboga plant.

Etymology

The name "18-Methoxycoronaridine" is derived from its chemical structure. The "18" refers to the position of the methoxy group on the coronaridine molecule. "Coronaridine" is a type of alkaloid found in various plants, including Tabernanthe iboga.

Usage

18-Methoxycoronaridine is primarily used in research settings to study the effects of addictive substances on the brain. It has been found to reduce self-administration of several drugs of abuse in animal models, including cocaine, morphine, and nicotine. It is thought to work by blocking the nicotinic acetylcholine receptor, which is involved in the rewarding effects of these substances.

Related Terms

  • Ibogaine: A naturally occurring psychoactive substance found in plants in the Apocynaceae family. It has been used in traditional medicine and spiritual practices, and is the parent compound of 18-Methoxycoronaridine.
  • Nicotinic acetylcholine receptor: A type of protein that is found in the brain and other tissues, which is involved in the transmission of signals in the nervous system. It is a target of many drugs of abuse, including nicotine and cocaine.
  • Neuroscience: The scientific study of the nervous system, including the brain. It encompasses a wide range of topics, from the molecular and cellular level to the level of systems, behavior, and cognition.

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